University of Groningen Hemostasis and anticoagulant therapy in liver diseases

Groningen Hemostasis and anticoagulant therapy in liver diseases

Thrombophilia, Anticoagulant Therapy, and Pregnancy Outcome in Women with Poor Obstetric History

Background: The role of anticoagulant medications in preventing placental mediated pregnancy complications in patients with and without thrombophilia has not been investigated well. One underlying cause is associated with adverse effects of anticoagulants in pregnancy including teratogenicity, complexities in dosing and management of anticoagulants during pregnancy and labor. We aimed to assess...

Effect of ferric sulfate and ferric chloride in controlling liver bleeding an animal model study

Introduction: Controlling parenchymal hemorrhage, especially in liver, is still one of the challenges surgeons face with when they try to save the patients’ lives despite improvements in surgical procedures. There is a research contest between the researchers in this field to introduce more effective methods. This study aimed to compare the hemostatic effect of ferric sulfate and ferric chlo...

Rituximab for Treatment of Hemophilia A with High-Responder Inhibitors

Background: The development of inhibitors is a complication factor replacement therapy in hereditary factor VIII deficiency. Several management options are available for the treatment of inhibitor. Rituximab, a monoclonal antibody against CD20, reduces inhibitor level in rare bleeding disorders. The aim of this study was to evaluate the effectiveness of rituximab in lowering or eliminating the ...

The peroxisome proliferator - activated receptors under epigenetic control in placental metabolism

4 Center for Liver, Digestive and Metabolic Diseases, Department of Pediatrics, University Medical 5 Center Groningen, University of Groningen, Groningen, the Netherlands 6 Research Center, Dr. von Hauner Children’s Hospital, Ludwig-Maximilians-Universität München, 7 München, Germany 8 Department of Obstetrics and Gynecology, University Medical Center Groningen, University of 9 Groningen, Groni...